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FLASH GENE
Symbol CD177 contributors: mct - updated : 28-11-2017
HGNC name CD177 antigen
HGNC id 30072
Location 19q13.2      Physical location : 43.857.824 - 43.867.479
Synonym name
  • neutrophil alloantigen NB1
  • polycythemia rubra vera 1
  • cell surface receptor
  • Synonym symbol(s) NB1, HNA2A, PRV1
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage erythroblasts, megakaryocytes, promyelocytes, and myelocytes lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal peptide
  • two highly homologous 188-residue cysteine-rich domains that share homology with UPAR domains
  • a highly hydrophobic C-terminal sequence probably encoding a GPI link
  • three N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY uPAR/CD59/Ly6 family of cell surface receptors
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION involved in the pathogenesis of immune neutropenias and transfusion reactions
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in neutrophils of patients with polycythemia vera and essential thrombocytemia
             
    Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in neonatal immune neutropenia and transfusion-related acute lung injury
    constitutional     --over  
    increased mRNA levels of both PRTN3 and CD177 in ANCA)-associated systemic vasculitis (AASV)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS