protein
| inhibitor of caspase 9, DIABLO releasing this inhibition |
|
interacting with DIABLO and with PRSS25 (interactions inhibit apoptotic suppressor activity) |
|
interact with FBXO7 (can mediate its ubiquitination by SCF ubiquitin protein ligase and thus have important implication in the regulation of BIRC2 function) |
|
is a client protein of the stress protein HSP90AB1 that prevents auto-ubiquitination and degradation of BIRC2, whose depletion would be sufficient to inhibit cell differentiation |
|
interacting with TRAF2 (BIRC2-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand) |
|
acting cooperatively with BIRC3 and XIAP via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation |
|
cooperatively interacts with oligomerized processed CASP9 in the apoptosome and blocks procaspase-3 activation |
|
dramatically increases the transcriptional activity of E2F1 on synthetic and CCNE promoters |
|
VGLL4 triggers a relocalization of BIRC2 from the cytoplasm to the nucleus |
|
USP19, a deubiquitinating enzyme, interacts with cellular BIRC2, BIRC3 |
|
binding and ubiquitinating CASP3 and CASP7 |
|
RIPK4 interacts with BIRC2 (Lys51 and Lys145 of RIPK4 are two critical AAs for BIRC2-mediated ubiquitination and NFKB activation) |
|
BIRC2, BIRC3 and the adaptor protein TRAF2 interacted with caspase-1-containing complexes |
|
SIN3B, together with other MYC regulatory members, maintain the steady-state level of MXD4, in part through inhibition of BIRC2-mediated degradation of MXD4 |
|
a ubiquitin-regulated signaling network centered on ITCH and BIRC2 controls the strength of NOD2 signaling |
|
XIAP and, to a lesser extent, BIRC2 were found to directly interact with RHOA independently of the RHOA activation status |
|
TNFSF10 -induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS2 and repressed by the E3 ligases BIRC2 and BIRC3 |
|
BIRC2, BIRC3 constitutively downregulate PACS2 by polyubiquitination and proteasomal degradation, thereby restraining TNFSF10-induced killing of liver cancer cells |
|
EGLN3 interferes with the association between RIPK1 and BIRC2, and attenuates RIPK1-induced NFKB1 activation |
|
BIRC2 interacts with CTBP2 via through BIR domains to regulates the steady-state levels of CTBP2 protein in the nucleus |
|
novel function of BIRC2 which involves protecting CTBP2 from degradation to stabilize its steady-state level |
|
BRD7 suppresses tumor growth and metastasis thus functioning as a tumor suppressor at least partially by negatively regulating the enhancer activity and expression of BIRC2 |