protein
| BIRC2 interacting protein (can mediate the ubiquitination of BIRC2 by SCF ubiquitin protein ligase and thus have important implication in the regulation of BIRC2 function) |
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interacting with exportin 1 (XPO1) |
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SKP1 binding prevented FBXO7 from contacting XPO1 |
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SKP1 can directly interact with FBXO7, a gene defective in PARK15-linked Parkinson disease |
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negative regulator of NFKB1 signalling |
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binds to, and mediates ubiquitin conjugation to BIRC2 and TRAF2, resulting in decreased RIPK1 ubiquitination and lowered NFKB1 signalling activity |
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functional relationship between FBXO7 and mitofusin 1 |
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interacts with proteins that are not substrates of the ubiquitin proteasome system, such as CDK6 and PSMF1 |
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FBXO7 ubiquitinated TOMM20, and its levels correlated with FBXO7 expression, indicating a stabilizing effect |