motifs/domains
| N-terminal glutamate-rich domain (ERD), contributing to FKBP8 biological activities , N-terminal LC3-interacting region (LIR) motif binding strongly to MAP1LC3A |
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multiple N terminal FK506 binding and peptidyl prolyl cis-trans isomerase (rotamase) domains |
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a tripartite tetratricopeptide repeat (TPR) domain, calcium/calmodulin-binding motif, that interacts with the heat shock protein 90 (HSP90) |
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a transmembrane motif (TM) |
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two EF-hand calcium binding sites |
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a region, referred to as the FKBP-C domain, that is highly related to FKBP12 |
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a trans-membrane domain at the very C terminus, which is unique among all the FKBP proteins and is required for targeting it to mitochondria |
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a COOH-terminal tail anchor |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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text
| localized predominantly at the outer membrane of the mitochondria and the endoplasmic reticulum (ER) membrane, and associated with the anti-apoptotic proteins BCL2 and BCLXL at these organelles, thus modulating apoptosis |
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associates with nascent plasma membrane ion channels in the endoplasmic reticulum (ER) |
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certain mitochondrial outer membrane proteins, including FKBP8 and BCL2, translocate from the mitochondria to the endoplasmic reticulum (ER) during mitophagy, thereby escaping degradation by autophagosomes |
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membrane chaperone that is localized predominantly to mitochondria |
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anchored in the outer mitochondrial membrane (OMM) and acts as a multifunctional adaptor with anti-apoptotic activity |
basic FUNCTION
| T cell binding protein FKBP for the immunosuppressive agents FK506-rapamycin |
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FKBP8/FK506 has immunosuppressive effects by inhibiting calcineurin that functions as a critical signaling molecule during T-cell activation |
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antagonizing HH signaling in neural tissues |
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playing a role in immunoregulation and basic cellular processes involving protein folding and trafficking |
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may be having a role in neurons associated with memory function |
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targeting Bcl-2 to mitochondria and inhibiting apoptosis |
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playing a role in TSC gene-dependent cell size regulation |
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may be a functional component of the apoptotic signaling network in the RPE cells and that such an effect could be independent of FK506 |
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playing a very minor, if any, role in FRAP1 activation |
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key player in regulating the function of BCL2 by antagonizing caspase-dependent degradation through the direct interaction with the flexible loop domain of BCL2, which contains the caspase cleavage site |
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important modulator in neuronal hedgehog signaling and in controlling cell size and as an endogenous inhibitor of MTOR |
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plays an important role on the stability of proteins |
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having a regulatory role on the caspase-mediated BCL2 down-regulation, which is inhibited by the overexpression of FKBP8 and thereby maintains cell survival function of BCL2 in cancer cells |
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promotes degradation of endogenous PTP4A3 protein via protein-proteasome pathway |
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may play a critical role in tumorigenesis |
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plays an important role in membrane protein biogenesis on the cytoplasmic side of the ER membrane, whose activity is negatively regulated by HSP90AA1 through the TPR domain |
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mediates the cis/trans interconversion of peptidyl prolyl bonds |
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translocation of FKBP8 is essential for the suppression of apoptosis during mitophagy |
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regulates signalling pathways such as cell survival, apoptosis, proliferation and metastasis |
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FKBP8 and BCL2 translocate from mitochondria to the endoplasmic reticulum during mitophagy, a form of autophagy responsible for the elimination of damaged mitochondria |
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evidence for a role of immunophilins, including FKBP3 and FKBP8, in Non-capacitative calcium entry (NCCE) mediated by TRPC6 |
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novel roles for FKBP8 and MAP1LC3A, which act together to induce mitophagy |