Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | FKBP6 | contributors: mct - updated : 23-11-2022 |
HGNC name | FK506 binding protein 6, 36kDa |
HGNC id | 3722 |
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Corresponding disease |
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Location | 7q11.23 Physical location : 72.742.154 - 72.772.641 | ||
Synonym name | |||
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Synonym symbol(s) | FKBP36, MGC87179 | ||
EC.number | 5.2.1.8 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | head to head |
text | FKBP6 and two truncated copies FKBP6T1 and FKBP6T2 |
STRUCTURE | 30.49 kb 9 Exon(s) 3 Copie(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
Map | see WBS1 |
regionally located | FKBP6 in the WBS1 deletion,FKBPGT1 in the centromeric,FKBP6T2 in the telomeric repeat regions flanking the WBS1 deletion |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
IMPRINTING
text
| might be imprinted in the testis | |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | dimer |
HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | chaperone/stress , enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic |
basic FUNCTION | |
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CELLULAR PROCESS | cell cycle,division,meiosis |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | SPGF77 |
Other morbid association(s) |
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Susceptibility | to male infertility |
Variant & Polymorphism other | allele A of c.216C>A seems to be a protective factor for the development of male infertility |
Candidate gene | hypofertility in WBS | |
Marker
Therapy target
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ANIMAL & CELL MODELS |
homozygous fkbp6-/- male mice are infertile |