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FLASH GENE
Symbol MAN2A2 contributors: - updated : 17-10-2007
HGNC name mannosidase, alpha, class 2A, member 2
HGNC id 6825
Location 15q25-q26.1      Physical location : 91.447.419 - 91.465.814
Synonym name
  • alpha-mannosidase type II, isoform X
  • manosidase, alpha-, type II, isozyme X
  • Synonym symbol(s) MANA2X
    EC.number 3.2.1.114
    DNA
    TYPE functioning gene
    STRUCTURE 18.00 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned   linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive ofhousekeeping
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic tail,
  • a single transmembrane segment (TM1)
  • a large COOH-terminal catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane (TM) protein
    basic FUNCTION
  • alpha-mannosidase, membrane type, involved in processing of Asp-linked (N) glycans
  • catalyzing the first committed step in the biosynthesis of complex N-glycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS