motifs/domains
| N-terminal ubiquitin-like domain partially overlapped by a leucine zipper domain |
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a central zinc finger of the PHD finger type, contributing to the opening and/or stabilization of dense chromocenter structures to support the recruitment of modifying enzymes, like HDAC and DNMT1, required for the replication and formation of pericentromeric heterochromatin , and crucial for recruitment of DNMT1 to DNA replication sites and for maintenance of DNA methylation in mammalian cells |
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conserved SRA (SET- and RING finger-associated) domain, involved in recognition of hemimethylated DNA |
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a tandem Tudor domain and a PHD finger, tethered by a 17-AA linker, and has been implicated to link histone modifications and DNA methylation |
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a C-terminal zinc finger of the ring finger type, involved in chromatin modification function with the ability to recruit EME1 following replication-associated DNA damage |
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two nuclear localization signals |
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phosphorylation sites for several kinases |
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a consensus Rb binding sequence |
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a methyl DNA binding domain, the SRA (SET and RING Associated) |
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domain, which shows strong preferential binding to hemimethylated |
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CG sites, the physiological substrate for DNMT1 |
SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,euchromosome
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| intracellular,nucleus,chromatin/chromosome,heterochromosome
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text
| enriched in pericentric heterochromatin of interphase nuclei, and this localization is dependent on H3K9 methylation |
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endogenous N-methylpurine DNA glycosylase (MPG) and UHRF1 were co-localized in the nucleoplasm |
basic FUNCTION
| functions to maintain CpG DNA methylation patterns through DNA replication by co-localizing with the DNA methyltransferase DNMT1 at chromatin |
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involved in the regulation of topoisomerase 2 alpha gene expression |
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RNA polymerase 2 transcription factor |
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nuclear protein binding to the TOP2A gene promoter and involved in DNA replication (expression is cell cycle regulated in normal cells but stably high throughout cell cycle in various cancer cell lines) |
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involved in cell proliferation by way of methylation-mediated regulation of certain genes |
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required for maintenance of CG DNA methylation, |
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and is required for the stable association of DNMT1 with chromatin |
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facilitate the optimal processing of DNA damage, consistent with previously described models and studies of chromatin remodeling during DNA repair |
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being an E3 ligase important for the maintenance of global and local DNA methylation |
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acting as a key factor for DNMT1 maintenance methylation through recognition of a fundamental unit of epigenetic inheritance, mCpG |
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required for proper heterochromatin formation in mammalian cells |
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histone-binding protein expressed only in proliferating cells |
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may serve as a focal point of transcriptional regulation mediated by EHMT2 and other chromatin modification enzymes |
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may play a role in the DNA methylation profile inheritance as well as in the histone code inheritance |
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crucial cofactor for maintenance of DNA methylation by DNMT1, is endowed with E3 ubiquitin ligase activity |
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both DNMT1 and UHRF1 coprecipitate with ubiquitin specific peptidase 7 (USP7), a de-ubiquitinating enzyme |
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required for cell cycle progression and epigenetic regulation |
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links epigenetic regulation with DNA replication |
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specifically binds to hemi-methylated DNA through its SRA and has an essential role in maintenance of DNA methylation by recruiting Dnmt1 to hemi-methylated DNA sites |
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its ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2 |
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UHRF2 and UHRF1 are not functionally redundant in DNA methylation maintenance, revealing the cell-cycle-dependent interaction between UHRF1 and DNMT1 as a key regulatory mechanism targeting DNMT1 for DNA methylation |
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UHRF1 is emerging as a cofactor that coordinates the epigenetic silencing of tumor suppressor genes |
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is required for growth and maintenance of the transformed phenotype in prostate cancer cells |
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UHRF1 controls DNA methylation at the promoters of tumour suppressor genes in prostate cancer cells |
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UHRF1 along with EZH2 coordinate epigenetic silencing of tumour suppressor genes in prostate tumours |
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plays an important role in DNA CpG methylation, heterochromatin function and gene expression |
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is protected by USP7 during G1 and S phases of the cell cycle |
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mediates cross-talk between H3K9 methylation and DNA methylation at the level of DNA methylation maintenance |
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UHRF1 is a critical negative regulator of KAT5, suggesting that UHRF1-mediated effects on TP53 may contribute, at least in part, to its role in tumorigenesis |
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UHRF1-dependent histone H3 ubiquitylation has a prerequisite role in the maintenance DNA methylation |
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plays a major role in the inheritance of some epigenetic marks from mother cells to daughter cells due to its particular structural domains |
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essential regulator of DNA methylation that is highly expressed in many cancers |
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