SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,centromere
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| RSF1 is enriched at mitotic centromeres |
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localizes at mitotic kinetochores and directly binds PLK1 |
basic FUNCTION
| involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SMARCA5 |
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plays a role in chromatin remodeling and transcriptional regulation that may contribute to tumorigenesis in ovarian cancer |
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possesses nucleosome-dependent ATPase activity, whereas RSF1 (HBXAP) functions as a histone chaperone |
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both the full-length RSF1 and SMARCA5 were required to form a functional RSF complex responsible for the growth suppression effects |
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its increased chromatin remodeling activity induce DNA strand breaks, activate the ATM/TP53-dependent DNA damage responses, and lead to growth arrest and apoptosis in cells with wild-type TP53 |
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contributes to malignant cell growth by cyclin D1 and ERK modulation |
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new function of chromatin remodeler RSF1 as a guard in DNA damage checkpoints and homologous recombination repair |
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contributes to hepatocellular carcinoma cell growth through regulation of cell cycle proteins |
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RSF1 is an essential centromeric component that recruits PLK1 to kinetochores and plays a crucial role in faithful cell division |
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role in histone H2A ubiquitination-mediated gene silencing |
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RSF1 regulates the dynamics of H2A histone modifications at mitotic centromeres and contributes to the maintenance of chromosome stability |
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is one of chromatin-remodeling factors, linked to the DNA damage response (DDR) and DNA repair |