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FLASH GENE

Symbol

CPM

contributors: mct - updated : 24-04-2020

HGNC name	carboxypeptidase M
HGNC id	2311

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q15      Physical location : 69.244.957 - 69.357.020
Synonym name	MAX-1 antigen
	kininase 1
Synonym symbol(s)	D12S1501
EC.number	3.4.17.12

DNA

TYPE	functioning gene
STRUCTURE	121.05 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   transcription factor
text structure	an upstream promoter sequence containing several transcription factor binding sites
	two unique functional promoters: one ('proximal') is immediately upstream of the coding region and contains GC-rich sequences and a typical TATA box whereas the other ('distal') consists almost entirely of repetitive elements

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001874 6 - 6683 NP_001865 50 443 - 2013 24108126 NM_198320 9 - 6627 NP_938079 50 443 - 2013 24108126 NM_001005502 9 - 6651 NP_001005502 50 443 - 2013 24108126

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta     highly Homo sapiens Respiratory lung         Homo sapiens Urinary bladder       highly   kidney tubule collecting duct   highly Homo sapiens   kidney tubule convoluted tubule distal tubule   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Urinary epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	hydrophobic domains at the N and C termini
	a conserved catalytic domain including six glycosylation sites

conjugated

GlycoP , MetalloP

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

zinc carboxypeptidase family

CATEGORY

enzyme , antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	carboxypeptidase M cleaving basic C terminal amino acids in monocyte to macrophage differentiation
	membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins 1)
	likely a cellular player in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
	could likely promote foam cell formation by acting in the lipid regulation process of macrophages
	inhibition of CPM, the key enzyme involved in the biosynthesis of BDKRB1 agonists, could exert the same beneficial effects to BDKRB1 antagonism in insulin resistance
	is a glycosylphosphatidylinositol anchored enzyme that plays an important role in the kallikrein-kinin system (KKS)

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein	activating peptide hormones at local tissue sites, before or after binding to their ligands
	close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
	spatial proximity between ACE and the endogenous CPM BDKRB1 signals, which play important r enables an ACE-evoked release of CPM
	BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in several tumor tissues tumoral     --over   in renal clear cell carcinomas tumoral   amplification     in well-differentiated liposarcomas/atypical lipomatous tumor

Susceptibility

to silicosis

Variant & Polymorphism other	rs12812500 variant of the CPM gene may increase silicosis susceptibility

Candidate gene
Marker	CPM is a novel marker in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
	identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors
Therapy target
	System Type Disorder Pubmed diabete type 2   therapeutic target in insulin resistance

ANIMAL & CELL MODELS