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FLASH GENE

Symbol

CHAF1A

contributors: mct/npt - updated : 16-04-2008

HGNC name	chromatin assembly factor 1, subunit A (p150)
HGNC id	1910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 4.402.659 - 4.443.393
Synonym name	CAF-1 subunit A
Synonym symbol(s)	CAF1, CAF-1, CAF1B, CAFA, CAF1P150, MGC71229, P150, CAF

DNA

TYPE	functioning gene
STRUCTURE	40.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 15 - 3344 - 956 - Bethke (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine adrenal gland       highly Lymphoid/Immune lymph node       highly Nervous brain         Reproductive male system prostate       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, G1, S, G2

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N terminal PEST domain

HOMOLOGY

interspecies

homolog to murine Chaf1a

Homologene

FAMILY

CATEGORY

regulatory , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	playing an essential role in eukaryotic chromatin assembly during DNA replication
	required for efficient S-phase progression in cells, and for coupling chromatin assembly with DNA replication
	major regulator of chromatin assembly during DNA repair
	key factor involved in histone deposition

CELLULAR PROCESS

nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of the chromatin assembly factor-1 (CAF-1) complex

INTERACTION

DNA

RNA

small molecule

protein	histone H3 and H4
	with the replication kinase CDC7-DBF4
	ASF1A is a highly conserved histone H3/H4 chaperone that synergizes with two other histone chaperones, CHAF1A and HIRA, in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly
	ANGEL1 has been shown to interact with CHAF1A, which has deadenylase activity, suggesting that ANGEL1 may recruit CHAF1A in EIF4E complexes

cell & other

REGULATION

Other

regulated by TSC1 and TSC2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to glioma

Variant & Polymorphism SNP	increasing the risk of glioma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS