Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCNB1IP1 contributors: mct - updated : 15-06-2022
HGNC name cyclin B1 interacting protein 1
HGNC id 19437
Location 14q11.2      Physical location : 20.779.529 - 20.801.457
Synonym name
  • enhancer of invasion 10
  • chromosome 14 open reading frame 18
  • RING-type E3 ubiquitin transferase CCNB1IP1
  • Synonym symbol(s) HEI10, C14orf18
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 21.91 kb     12 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1470 31.4 277 - 2010 21779533
    6 splicing 1270 31.4 277 - 2010 21779533
    7 splicing 1681 31.4 277 - 2010 21779533
    8 splicing 1651 31.4 277 - 2010 21779533
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
     salivary gland   highly
     stomach   highly
    Endocrineadrenal gland   moderately
     thyroid   highly
    Hearing/Equilibriumear   moderately
    Nervousbrain   lowly
    Reproductivefemale systemuteruscervix moderately
    Respiratorylung   lowly
    Urinarykidney   lowly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger motif in the N terminus
  • a coiled-coil domain
  • cyclin and cyclin-dependent kinase phosphorylation sites in the C terminus
  • conjugated PhosphoP , Other
    HOMOLOGY
    interspecies homolog to rattus Ccnb1ip1 (89.5 pc)
    homolog to murine Ccnb1ip1 (88.8 pc)
    Homologene
    FAMILY
  • E3 ubiquitin ligase family
  • RING-finger family ubiquitin ligase
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text may associate with segregating chromosomes during metaphase and anaphase
    basic FUNCTION
  • acting as an E3 ubiquitin-protein ligase
  • modulating cyclin B levels and participating in the regulation of cell cycle progression through the G2 phase
  • it may be commonly involved in coordinating cell cycle with cell migration and invasion
  • CCNB1IP1 is essential for the crossover/non-crossover differentiation process
  • as with RNF212, dosage sensitivity for CCNB1IP1 indicates that it is a limiting factor for crossing over
  • mediates meiotic recombination and also plays roles in cell proliferation
  • is likely a unique type of structure-based signal transduction protein
  • transcriptional regulation of CCNB1IP1, is important in meiotic crossing-over and G2/M transition of the mitotic cell cycle
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CCNB1 and UBE2L3
  • regulates cell cycle by interacting with cyclin B and promoting its degradation
  • direct interaction between CCNB1IP1 and the tumor suppressor Merlin, encoded by the NF2 gene
  • CNTD1 coordinates processes of maturation of Meiotic crossovers (COs) by regulating the association between the RING finger proteins CCNB1IP1 and RNF212 and components of the CO machinery
  • RNF212 and CCNB1IP1 define an axis-associated, SUMO-ubiquitin-proteasome relay that mediates turnover of the subset of recombination factors that act after DMC1-promoted homolog pairing
  • cell & other
    REGULATION
    Other autoubiquitinated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with HMGIC t(14;12) (q11;q14) in uterine leiomyoma
    constitutional     --over  
    delayed entry into mitosis caused by overexpression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in wild-type mice, Hei10 accumulates at designated crossover sites, suggesting that it also has a late role in implementing crossing over