SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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text
| outside of cisternae and mostly in the cis-Golgi |
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colocalized with HIP1 in Golgi apparatus of neurons |
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could be transported to the nucleus by HIP1, a NLS containing nucleo-cytoplasmic shuttling protein |
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basic FUNCTION
| cell death-promoting protein, recruiting CASP8 into an heterotrimer complex (HIP1/ESRRBL1) |
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inducing apoptosis by releasing apoptosis inducing factor and cytochrome c from mitochondria, activation of caspase-1 and caspase-3, and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II |
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might contribute to neuronal death in Huntington disease |
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ccould interact with the putative promoter sequence of caspase-1 and increased the expression of the downstream gene suggesting that it could act as transcription regulator |
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RYBP and IFT57 may functionally interact in the apoptotic processes that accompany normal murine neural development |
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multifunctional protein that is involved in the regulation of apoptosis |
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not essential for intraflagellar transport, but is required for efficient intraflagellar transport |
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transcription regulatory mechanism of REST by IFT57 may contribute to the deregulation of transcription observed in the cell model of Huntington disease |
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pro-apoptotic protein that induces CASP8 mediated apoptosis in cell |
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could act as an important transcription regulator in cell regulating a vast array of genes, particularly transcription factors and at least, in part, play a role in transcription deregulation observed in Huntington disease |
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the IFT components IFT52 and IFT57 were found to act together with IFT20 to regulate T cell antigen receptor (TCR) and transferrin receptor (TfR) recycling |