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FLASH GENE
Symbol PAPOLG contributors: npt - updated : 19-07-2006
HGNC name poly(A) polymerase gamma
HGNC id 14982
Location 2p15      Physical location : 60.983.364 - 61.029.220
Synonym name
  • SRP RNA 3' adenylating enzyme/PAP2
  • polynucleotide adenylyltransferase gamma
  • neo-poly(A) polymerase
  • Synonym symbol(s) PAP2, PAPG, SRPRNA, FLJ12972, FLJ11805, FLJ13482, FLJ14187, MGC133307, MGC133308
    EC.number 2.7.7.19
    DNA
    TYPE functioning gene
    STRUCTURE 42.72 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text displaying distinct mRNA splice varaints (Topalian)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4252 82.8 736 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved cyclin recognition motif
  • a multiple potential cyclin-dependent kinase (Cdk) phosphorylation sites
  • a U1A protein-interacting region in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • poly (A) polymerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polynucleotide adenylyltransferase
  • catalyzing template-independent (adenylation) extension of the 3' end of a DNA/RNA strand
  • exhibiting both non specific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA processing,mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • component of pre RNA polyadenylation complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • U1A protein
  • cell & other
    REGULATION
    inhibited by U1A protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS