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FLASH GENE
Symbol TXNL1 contributors: SGE/np - updated : 12-12-2007
HGNC name thioredoxin-like 1
HGNC id 12436
Location 18q21.31      Physical location : 54.270.054 - 54.305.920
Synonym name
  • thioredoxin-like, 32kDa
  • thioredoxin-related protein 1
  • Synonym symbol(s) TXL, TRP32, TXNL, TXL-1
    DNA
    TYPE functioning gene
    STRUCTURE 35.87 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1285 - 289 - Kim (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal Trx domain
  • a C-terminal domain of unknown function
  • HOMOLOGY
    interspecies homolog to murine Txnl
    Homologene
    FAMILY
  • thioredoxin family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • having thioredoxin-like reducing activity (protein-disulfide reduction)
  • might be involved in the cellular response to sugar starvation stress
  • is a redox-active cofactor of the 26S proteasome (Andersen 2009)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PSMD14 (Andersen 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS