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FLASH GENE
Symbol EIF4G3 contributors: mct - updated : 10-05-2014
HGNC name eukaryotic translation initiation factor 4 gamma, 3
HGNC id 3298
Location 1p36.12      Physical location : 21.132.975 - 21.503.340
Synonym symbol(s) EIF4GII
DNA
TYPE functioning gene
STRUCTURE 244.00 kb     31 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large, middle, alpha helical domain RNA binding
  • a C-terminal eIF-5 domain, maybe involved in interactions with eIF-2
  • HOMOLOGY
    interspecies homolog to mammalian eIF-4G (EIF4G)
    intraspecies paralog to EIF4G1,EIF4G2
    Homologene
    FAMILY eukaryotic translation initiation factor EIF4 family
    CATEGORY chaperone/stress , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • scaffolding protein binding of mRNA cap structure to ribosome 43S
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component scaffold protein for the assembly of eIF4A, eIF4B, eIF4E, MNK1, EIF4EBPs, PABPC1 to form the eukaryotic translation initiation complex eIF4F
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to EIF4E, EIF4A, EIF3
    cell & other
    REGULATION
    Other cleaved upon picarnovirus infection
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS