SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,interspace
|
| intracellular,cytoplasm,organelle,mitochondria,matrix
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus
|
text
| localized both in the cytoplasm and nucleus and is translocated by stress or mitogen stimulation of cells |
|
secreted from various cells and oxidation at C106 facilitated the secretion and also localized in microdomains |
|
associated with complex I in mitochondria |
|
associated with lipid rafts |
basic FUNCTION
| functioning as a positive regulator of androgen receptor |
|
involved in the oxidative stress response |
|
protecting against mitochondrial damage and may be protecting neurons from various stressful stimuli |
|
neuroprotective transcriptional co-activator that may act in concert with NONO and SFPQ to regulate the expression of a neuroprotective genetic program |
|
having a functional role in scavenging mitochondrial H2O2 because of its physiological action as an atypical peroxiredoxin-like peroxidase |
|
multi-functional protein that plays roles in transcriptional regulation and anti-oxidative stress function |
|
involved in cancer by promoting Ras signaling and suppressing PTEN-induced apoptosis |
|
may play roles in coordinating responses to oxidative damage and suppression of cell death |
|
protect cells against hypoxia-induced cell death and is required for their adaptation to severe hypoxic stress |
|
degrades aggregated TTR to protect against the onset of FAP (familial amyloidotic polyneuropathy) |
|
upstream activator of HIF1 function in cancer cells and its oncogenic activity stems from its ability to increase a cell resistance to hypoxic stress |
|
plays roles in transcriptional regulation and anti-oxidative stress |
|
integral mitochondrial protein that plays a role in maintenance of mitochondrial complex I activity |
|
crucial for full activation of AKT1 upon oxidative injury, which serves as one explanation for the protective effects of PARK7 |
|
exerts an important role in the regulation of the AKT1 pathway in response to oxidative stress and neuronal protection |
|
important for proper mitochondrial function and acts downstream of, or in parallel to, PINK1 |
|
is in a pathway parallel to that of PINK1/parkin and both of these pathways, and their carefully balanced activity, are critical for mitochondrial function |
|
works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment |
|
influences mitochondrial function and morphology through an oxidative stress pathway |
|
function may either contribute to the regulation of autophagy or mitigate the downstream effects of ROS |
|
antioxidant function of PARK7 by increasing TXN expression via NFE2L2-mediated transcriptional induction |
|
multifunctional protein that acts as an antioxidant and a transcriptional regulator |
|
cytoprotective activity of PARK7 is mediated by the transcriptional induction of the TXN gene through the NFE2L2 pathway |
|
serves as scavengers for reactive carbonyl species may provide a new insight into the causation of Parkinson disease |
|
converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione |
|
is closely associated with the differentiation of neural stem cells |
|
stimulates the differentiation of human mesenchymal stem cells to osteoblasts and induces angiogenesis in endothelial cells through activation of FGFR1 signalling |
|
regulates retinal pigment epithelium (RPE) responses to oxidative stress |
|
function in lipid rafts, which may contribute the pathogenesis of Parkinson disease |
|
may be implicated in the regulation of vascular contractility and blood pressure |
|
function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival |
|
PARK7 and consequently its products are components of a novel pathway that stabilizes mitochondria during cellular stress |
|
exerts its antioxidant activities, at least partly through regulation of PON2 |
|
|