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FLASH GENE
Symbol GTF2A1L contributors: mct - updated : 11-05-2020
HGNC name general transcription factor IIA, 1-like
HGNC id 30727
Location 2p16.3      Physical location : 48.844.936 - 48.960.284
Synonym name
  • GTF2A1-like factor
  • TFIIA-alpha/beta-like factor
  • general transcription factor IIA 1-like
  • TFIIA tau
  • testis secretory sperm-binding protein Li 230m
  • Synonym symbol(s) MGC26254, ALF, GTF2A1LF
    DNA
    TYPE functioning gene
    STRUCTURE 61.83 kb     8 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure a unique CpG-specific methylation pattern at the ALF promoter precedes expression in pachytene spermatocytes
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1668 52.4 478 - 2001 11159353
    8 - 1608 - 444 - 2001 11159353
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • organized into four regions that are characterisitc of all TFIIA large subunits, including the conserved N and C terminal domains
  • conserved regions I and IV and acidic region III but a distinct region II
  • HOMOLOGY
    interspecies ortholog to murine Gtf2a1lf
    intraspecies paralog to TFIIA alpha/beta
    Homologene
    FAMILY
  • TFIIA subunit 1 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • testis specific transcription factor, that may function in spermatogenesis, especially in spermiogenesis
  • is associated with undifferentiated cells during development, yet is down-regulated at the chromatin level upon cellular differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcription co-activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding in conjunction with GTF2A2 and TBP (the TATA-binding protein)
  • RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by multivalent zinc finger chromatin insulator protein CTCF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    abnormal expression might be partial cause for infertility
    Susceptibility
  • to non-obstruction azoospermia (NOA) with abnormal FSH level
  • Variant & Polymorphism other
  • rs11677854 of GTF2A1L might be additional valuable molecular predictive markers for assessing the treatment of NOA patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • short core promoter drives expression of the Alf transcription factor in reproductive tissues of male and female mice