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FLASH GENE
Symbol BBX contributors: mct/npt - updated : 19-09-2017
HGNC name bobby sox homolog (Drosophila)
HGNC id 14422
Location 3q13.12      Physical location : 107.241.782 - 107.530.047
Synonym name
  • HMG-BOX transcription factor BBX
  • x 001 protein
  • Ag recognized by Treg cells
  • Synonym symbol(s) MDS001, HSPC339, HBP2, ARTC1
    DNA
    TYPE functioning gene
    STRUCTURE 288.39 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 9037 - 941 - Sanchez-Diaz (2001)
    17 splicing 8947 101.6 911 - Lee (unpublished)
    17 - 8028 - 628 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivemouthtooth    Homo sapiens
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
     brainhindbraincerebellum moderately Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast Homo sapiens
    cell lineage
    cell lines neuronal tumor cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing CNS
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • BBX plays an important role during the odontoblast differentiation of human DPSCs/progenitors
  • maybe associated with CNS development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BBX is a downstream target of NFIX during development of the forebrain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS