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FLASH GENE
Symbol CRNKL1 contributors: npt/mct - updated : 21/11/2008
HGNC name crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
HGNC id 15762
Location 20q12      Physical location : 20.015.012 - 20.036.690
Synonym name
  • Crn, crooked neck-like 1 (Drosophila)
  • crooked neck-like 1 protein
  • Synonym symbol(s) CRN, CLF, SYF3, CGI-201, MSTP021, HCRN
    DNA
    TYPE functioning gene
    STRUCTURE 21.68 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4406 100 848 - Chung (2002)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • HAT (half-A-TPR) repeat
  • many tetratricopeptide repeats
  • HOMOLOGY
    interspecies ortholog to Drosophila crooked neck
    Homologene
    FAMILY
  • crooked-neck family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text co-localizes with the SR and Sm protein splicing factors in discrete subnuclear domains implicated in snRNP biogenesis
    basic FUNCTION
  • essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS