basic FUNCTION
| sentrin-specific protease that preferentially removes sentrin from sentrinized proteins in the nucleus |
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SUMO-specific proteases involved in the regulation of apoptosis |
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degrading UBL1 and SMT3H2 conjugates and releases the monomers |
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acting on sumoylated PML |
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acting as a thiol protease |
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involved in Ubl conjugation pathway |
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enhancing the transcription activity of c-Jun |
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playing a role in desumoylation |
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promotes stress-induced apoptosis by interacting with and desumoylating SIRT1 |
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playing a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability |
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controlling Epo production |
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may itself be a target for SUMO1 modification occurring at a nonconsensus site |
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lacks a clear preference for any particular SUMO isoform |
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important role in the de-SUMOylation of ELK1, and therefore an integral role in determining the ELK1-dependent transcriptional programme |
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important role in the regulation of ELK1-mediated gene expression in response to mitogenic signalling cues |
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could abrogate CAPN2 sumoylation, causing an inhibition on calpain-2-dependent activity and cell motility |
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alters VEGF levels by directly regulating HIF1A stability during fetal development |
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participates in the development of prostate neoplasia |
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regulates VEGF expression via modulating the nuclear stability of HIF1A and initiates the onset of angiogenesis in DYNLL1 |
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is essential for the development of early T and B cells |
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essential role of SENP1 in PPARGC1A transcriptional activity and also in mitochondrial biogenesis |
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is essential for expression of nuclear mitochondrial genes |
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SENP1 can promote the expression of mitochondrial genes through de-SUMOylation |
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critical role for SENP1-mediated deSUMOylation in promoting PIN1 function during tumorigenesis |
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chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis and SENP1 and SENP2 are important mediators of this control |
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is a novel regulator in adipogenesis |
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is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation |
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SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression |
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SENP1 is an essential regulator of the balance between SUMOylation and deSUMOylation during lung development, specifically affecting the proliferation and differentiation status of AT2 cells |
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SENP1 promotes sepsis via activating the TGFBR2 signaling |