SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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text
| nucleolar retention of DDX21 is dependent on the presence of nucleostemin in the nucleolus |
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inhibition of JNK signalling results in partial delocalization of DDX21 from the nucleolus to the nucleoplasm, increased nucleolar mobility of DDX21 and inhibition of rRNA processing |
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CASP3/6 cleaves DDX21 at D126 and promotes its translocation from the nucleus to the cytoplasm in response to virus infection |
basic FUNCTION
| double stranded unwinding RNA and folding single stranded RNA |
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multifunctional nucleolar protein involved in ribosomal RNA processing |
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DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells |
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multifaceted role of DDX21 in multiple steps of ribosome biogenesis, providing evidence implicating a mammalian RNA helicase in RNA modification and Pol II elongation control ( |
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SIRT7 and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity |
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role for DDX21 in the proliferation of gastric cancer cells via the Cyclin D1 and CDK2 pathways |
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is a nuclear protein involved in rRNA processing and RNA unwinding |
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potential role of DDX21 cleavage in the innate immune response to virus |
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DDX21 and MOV10 RNA helicases limit viral infection and replication of SARS-CoV-2, but in contrast, DDX1, DDX5, and DDX6 are required for SARS-CoV-2 infection |
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nucleolar protein harboring ATP-dependent double-stranded RNA unwinding activities, essential in rRNA processing and ribosome biogenesis |