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FLASH GENE

Symbol

MAPK10

contributors: mct/pgu - updated : 20-06-2015

HGNC name	mitogen-activated protein kinase 10
HGNC id	6872

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q21.3      Physical location : 86.936.276 - 87.374.283
Synonym name	C-Jun kinase 3
	stress activated protein kinase JNK3
	stress activated protein kinase beta
	MAP kinase p49 3F12
Synonym symbol(s)	JNK3, PRKM10, P493F12, FLJ12099, FLJ33785, JNK3A, p54bSAPK, p493F12
EC.number	2.7.11.24

DNA

TYPE	functioning gene
STRUCTURE	338.17 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138982 14 splicing 4186 NP_620448 52 464 - 2011 22047447 JNK3- alpha 2, or variant 2 both nonvisual arrestins directly bind JNK3alpha2 and its upstream activator MAP2K4, and the affinity of ARR3 for these kinases is higher than that of ARR2 enhanced the association between ARR3 with MAP2K4 while reducing ARR3 binding to MAP2K7 NM_002753 13 splicing 3727 NP_002744 47 422 - 2007 17680991 JNK3- alpha 1 or variant 1 NM_138980 14 - 4213 NP_620446 - 426 - 2007 17680991 variant 3, or stress activated protein kinase beta NM_138981 9 - 3511 NP_620447 - 277 - 2007 17680991

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain diencephalon hypothalamus   highly   brain forebrain cerebral cortex   highly   brain hindbrain cerebellum   highly   spinal cord         Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular striatum skeletal     Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

tyrosine kinase catalytic domain

HOMOLOGY

interspecies

homolog to murine Mapk10

Homologene

FAMILY	protein kinase superfamily
	CMGC Ser/Thr protein kinase family
	MAP kinase subfamily

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	mediating apoptosis in central nervous system and role in the development of brain tumors
	playing an established role in both neuronal differentiation and apoptosis
	having a pivotal role in regulation of ceramide biosynthesis in cerebral ischemia/reperfusion
	critical mediator of mutant HTT toxicity, providing a molecular basis for mutant HTT-induced inhibition of fast axonal transport
	mediates activation of LASS6 in cerebral ischemia/reperfusion
	critically involved in stress-induced deficit of contextual fear
	important enzymes in the pathology of diverse neurological disorders
	mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	components of the two MAPK cascades, MAP3K5-MAP2K4-MAPK10 and RAF1-MAPK1-MAP2K1 interacting with arrestins

INTERACTION

DNA

RNA

small molecule

protein	interacting with ARR3 (multiple residues on the non-receptor-binding side of ARR3 are crucial for MAPK10 activation)
	protects beta-cells from apoptosis and dysfunction mainly through maintenance of a normal IRS2 to AKT2 signaling pathway
	ARR3 binds MAPK10, MAP2K4, and MAP3K5
	ARR3 promotes MAPK10 phosphorylation by MAP2K7
	MAPK10 interacts with the non-receptor-binding side of ARR3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
Therapy target

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
Therapy target

ANIMAL & CELL MODELS

Jnk3 null mice showed an increase in pik3cb transcript and protein, together with an increase in PI3K activity and phosphorylation of AKT