basic FUNCTION
| acts as a novel regulatory component of replicative senescence, which requires PTEN as a mediator and involves in a translational regulatory mechanism |
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ING1-RSL1D1 axis functions as a novel pro-apoptotic regulator in response to DNA damage |
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RSL1SD1, PCNA, and CCNA2, which promote cell cycle progression, are repressed permanently in senescent cells |
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promotes hepatocellular carcinoma proliferation by activating c-MYC expression |
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is implicated in various process including cell cycle regulation, apoptosis, and tumor metastasis |