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FLASH GENE
Symbol RSL1D1 contributors: mct - updated : 28-03-2018
HGNC name ribosomal L1 domain containing 1
HGNC id 24534
Location 16p13.13      Physical location : 11.928.054 - 11.945.442
Synonym name
  • PBK1 protein
  • cellular senescence-inhibited gene protein
  • CATX-11
  • Synonym symbol(s) DKFZP564M182, PBK1, L12, CSIG, CATX11, CSIG, UTP30
    DNA
    TYPE functioning gene
    STRUCTURE 17.39 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5137 54 490 - 2015 25749381
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ribosomal L1 domain in its N-terminus
  • the ribosomal L1 domain and Lys-rich region of RSL1D1 are both critical for RSL1D1 to act as a regulator of cell proliferation and cellular senescence
  • HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein L1p/L10e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleolus
    text
  • abundantly expressed in growing human diploid fibroblast cells, but its expression decreases upon replicative senescence
  • basic FUNCTION
  • acts as a novel regulatory component of replicative senescence, which requires PTEN as a mediator and involves in a translational regulatory mechanism
  • ING1-RSL1D1 axis functions as a novel pro-apoptotic regulator in response to DNA damage
  • RSL1SD1, PCNA, and CCNA2, which promote cell cycle progression, are repressed permanently in senescent cells
  • promotes hepatocellular carcinoma proliferation by activating c-MYC expression
  • is implicated in various process including cell cycle regulation, apoptosis, and tumor metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GNL3-interacting protein
  • ING1 is a binding partner that interacts with RSL1D1 (after UV irradiation, ING1 increases its protein expression, translocates into the nucleolus and binds RSL1D1)
  • RSL1D1 is a direct target of E2F1
  • plays an important role in regulating cell proliferation and cellular senescence progression through inhibiting PTEN
  • cell & other
    REGULATION
    Other may likely be transcriptionally repressed during cellular senescence
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with an aggressive phenotype and a poor prognosis in patients with prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS