basic FUNCTION
| inhibiting signal transduction by increasing the GTPase activity of Gprotein alpha subunits thereby driving them into their inactive GDP-bound form |
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limits microglial-derived TNF secretion and regulates the functional outcome of inflammatory stimuli in the ventral midbrain |
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regulates ovarian cancer cell growth and survival |
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is a negative regulator of NFKB1 in microglia |
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plays likely an important role in determining macrophage activation responses |
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is an important regulator of cell survival and chemoresistance in ovarian cancer |
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plays an important function in osteoclast differentiation |
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may regulate dendritic cell proliferation and maturation, as well as the subsequent stimulation of T-cell proliferation and maturation, and osteoclast differentiation and activation |