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FLASH GENE
Symbol RGS13 contributors: mct - updated : 08-06-2011
HGNC name regulator of G-protein signaling 13
HGNC id 9995
Location 1q31.1      Physical location : 192.605.281 - 192.629.387
Synonym symbol(s) MGC17173
DNA
TYPE functioning gene
STRUCTURE 24.11 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1498 19 159 - 2002 11875076
6 - 1458 19 159 - 2002 11875076
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   highly
Digestiveliver    
Lymphoid/Immunelymph node   highly
 tonsils    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
taste 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RGS domain
  • HOMOLOGY
    interspecies homolog to C.elegans F16h9.1a
    Homologene
    FAMILY
  • Regulator of G protein Signaling (RGS) protein family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • inhibits CREB-dependent transcription of target genes through disruption of complexes formed at the promoter
  • restricts certain GPCR-mediated biological responses of human mast cells
  • scaffold that control diverse signaling pathways by modulating signalosome formation and by accelerating the GTPase activity of heterotrimeric G protein
  • inhibited cyclic AMP-dependent protein kinase (PKA)-induced gene expression through interactions with the transcription factor cAMP-response element-binding (CREB1) protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by PRKACA (PRKACA activation also leads to increased steady-state RGS13 expression through RGS13 phosphorylation, which inhibits RGS13 protein degradation)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS