Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GPS2 | contributors: mct - updated : 24-01-2015 |
HGNC name | G protein pathway suppressor 2 |
HGNC id | 4550 |
|
Location | 17p13.1 Physical location : 7.215.977 - 7.218.658 |
Synonym symbol(s) | AMF-1, MGC104294, MGC119287, MGC119288 |
DNA |
TYPE | functioning gene |
STRUCTURE | 2.68 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal |
Text | brain |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
conjugated | sumoylated |
HOMOLOGY |
interspecies | homolog to Arabibopsis fus6 (copII) |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus,nucleoplasm |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling | signal transduction |
a component | integral component of a deacetylase complex (GPS2-associated deacetylase complex might function in concert with hMSH4-hMSH5 during the process of homologous recombination) |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | can be modified by the small ubiquitin-like modifier (SUMO) SUMO1 but not SUMO2 or -3 |
posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |