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FLASH GENE
Symbol MTPN contributors: - updated : 23-03-2007
HGNC name myotrophin
HGNC id 15667
Location 7q33      Physical location : 135.611.504 - 135.662.204
Synonym name granule cell differentiation protein
Synonym symbol(s) FLJ31098, GCDP, V-1
DNA
TYPE functioning gene
STRUCTURE 50.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three ANK repeats
  • putative phosphorylation sites for protein kinase C and caseine kinase 2
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a potential role in cerebellar morphogenesis
  • playing a potential role in differentiation of cerebellar neurons, particulary of granule cells
  • increasing the transcript levels of protooncogenes,beta-myosin heavy chain,ANF and markers of cardiac hypertrophy
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RELA (initiating cardiac hypertrophy )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for cardiac hypertrophy and heart failure
  • Marker
    Therapy target
    ANIMAL & CELL MODELS