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FLASH GENE
Symbol TRIM36 contributors: mct - updated : 02-02-2009
HGNC name tripartite motif-containing 36
HGNC id 16280
Location 5q22.3      Physical location : 114.460.466 - 114.516.243
Synonym name
  • zinc-binding protein Rbcc728
  • RING finger protein 98
  • tripartite motif protein 36
  • Synonym symbol(s) RBCC728, HAPRIN, RNF98
    DNA
    TYPE functioning gene
    STRUCTURE 55.79 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S2065 - D5S659 - TRIM36 - D5S2055 - D5S404 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 4456 82.9 728 - Balint
    2 splicing 760 6.6 60 - Balint
  • lacking several 3' exons
  • having a much shorter and alternate 3' segment compared to variant 1
  • 2 splicing 906 6.6 61 - Balint
  • lacking several 3' exons
  • having a much shorter and alternate 3' segment compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING C3HC4-type zinc finger
  • two B box domains (one type 1 and one type 2), linked to a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a COS (C-terminal subgroup one signature) domain
  • a fibronectin type III domain
  • RFP-like domain
  • a C-terminal domain of unknown function (SPRY)
  • HOMOLOGY
    interspecies homolog to rattus Trim36 (93 pc)
    homolog to murine Trim36 (92.6 pc)
    intraspecies homolog to MID1
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-I TRIM family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in the acrosomal region of elongated spermatids and mature sperm
    basic FUNCTION
  • involved in acrosome reaction, fertilization, and embryogenesis (Miyajima 2009)
  • might be involved in the prostate tumorigenesis
  • having a ubiquitin ligase activity (Miyajima 2009)
  • potentially associated with chromosome segregation and that an excess of TRIM36 may cause chromosomal instability(Miyajima 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with centromere protein-H, one of the kinetochore proteins (Miyajima 2009)
  • potentially associated with chromosome segregation in collaboration with CENPH and overexpression of TRIM36 may have an effect on chromosomal instability (Miyajima 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the vast majority of prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be useful for establishing new chemotherapy for many cancers, including prostate cancers (Miyajima 2009)
    ANIMAL & CELL MODELS