basic FUNCTION
| playing a role in the cell polarization |
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activating RAC and CDC42 to a PKC signaling |
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acts as a scaffold protein to facilitate atypical protein kinase C-mediated phosphorylation of cytoplasmic protein complexes, leading to epithelial and neuronal cell polarization (Cline 2007) |
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in the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cytoplasm (Cline 2007) |
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important link between cell recognition mediated through the NPHS1/KIRREL complex and PARD6A and PARD6B-dependent polarity signaling (this molecular interaction is essential for establishing the three-dimensional architecture of podocytes at the kidney filtration barrier) (Hartleben 2008) |
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PARD3, PARD3B, atypical protein kinase C (aPKC) and PARD6A, PARD6B critically regulate the apical membrane development required for epithelial organ development (Horikoshi 2009) |
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PARD6B and PRKCI control mitotic spindle orientation in polarized epithelia and, furthermore, that PRKCI coordinately regulates multiple processes to promote morphogenesis |