Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PARD6B contributors: mct/npt - updated : 13-03-2010
HGNC name par-6 partitioning defective 6 homolog beta (C. elegans)
HGNC id 16245
Location 20q13.13      Physical location : 49.348.080 - 49.370.277
Synonym name
  • PAR-6 beta
  • par-6 (partitioning defective 6, C.elegans) homolog beta
  • Synonym symbol(s) PAR6B, PAR-6B
    DNA
    TYPE functioning gene
    STRUCTURE 22.20 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4625 - 372 - Noda (2001)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, fetal kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one OPR domain
  • a PDZ (DHR) domain
  • a pseudo-CRIB domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Pard6b
    intraspecies homolog to PARD6A
    homolog to PARD6G
    Homologene
    FAMILY
  • PARD6 family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocalized to membrane ruffles
  • colocalizes in the nucleus with Tax, a transcriptional activator of the human T-cell leukemia virus type 1 long terminal repeat (Cline 2007)
  • localized to the apical surface in human epithelial cells
  • basic FUNCTION
  • playing a role in the cell polarization
  • activating RAC and CDC42 to a PKC signaling
  • acts as a scaffold protein to facilitate atypical protein kinase C-mediated phosphorylation of cytoplasmic protein complexes, leading to epithelial and neuronal cell polarization (Cline 2007)
  • in the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cytoplasm (Cline 2007)
  • important link between cell recognition mediated through the NPHS1/KIRREL complex and PARD6A and PARD6B-dependent polarity signaling (this molecular interaction is essential for establishing the three-dimensional architecture of podocytes at the kidney filtration barrier) (Hartleben 2008)
  • PARD3, PARD3B, atypical protein kinase C (aPKC) and PARD6A, PARD6B critically regulate the apical membrane development required for epithelial organ development (Horikoshi 2009)
  • PARD6B and PRKCI control mitotic spindle orientation in polarized epithelia and, furthermore, that PRKCI coordinately regulates multiple processes to promote morphogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a quaternary complex with protein kinase C zeta (PRKCZ), PARD3 and CDC42
  • like CDC42, the PARD6B/PRKCI complex controls mitotic spindle orientation during cell division to correctly position the nascent apical surface in a growing cyst ()
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PARD3 (first PDZ domain)
  • GTP bound,CDC42
  • PKC iota/lambda and PKC zeta
  • PNMA1
  • PRKCI protects PARD6B from proteasomal degradation, mechanism ensuring that PARD6B is constitutively bound to and able to signal through PRKCI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS