basic FUNCTION
| cell shape and cell size control |
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linking Rho GTPases to cytoskeleton reorganisation and nuclear signaling |
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playing a role in pancreas ductal adenocarcinoma cellular migration and invasion |
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mediator of filopodia formation, playing a role in the reorganisation of the actin cytoskeleton (suggesting a role for the Golgi in cell morphogenesis) |
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playing a role in the regulation of cytoskeletal organization and cell and/or extracellular matrix adhesion, and in neural tube development |
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in response to HGF, Gab1 and Pak4 synergize to enhance epithelial cell dispersal, migration and invasion |
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key integrator of cell migration and invasive growth downstream from the Met receptor |
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functions in TNF-alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor |
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mediates morphological changes through the regulation of GEF-H1 |
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can negatively regulate the activation of Rho through a direct protein-protein interaction with G protein-linked Rho GEFs |
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determine podosome size and number in macrophages through localized actin regulation |
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increases cell migration speed in synergy with LIMK1 in prostate |
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disrupts mammary acinar architecture and promotes mammary tumorigenesiscancer cells |
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regulates cytoskeletal organization, and controls cell growth, proliferation, and survival |
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may play a critical role in the regulation of neural progenitor cell proliferation and in establishing the foundation for development of the adult brain |
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regulates cytoskeletal architecture, and controls cell proliferation and survival |
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required for regulation of the cell-cycle regulatory protein CDKN1A, and for control of cell-cycle progression |
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critical molecule coordinating cytoskeletal systems for efficient cell migration |
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regulates regulatory myosin light chain phosphorylation and myosin contractility during FCGR-mediated phagocytosis |
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PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart |
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involved in the regulation of the G1 phase and the G2/M transition of the cell cycle |
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has a key role in the oncogenic transformation of breast cells |
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is an important regulator of endometrial cancer cell migration and invasion |