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FLASH GENE
Symbol MUC13 contributors: npt - updated : 20-09-2006
HGNC name mucin 13, cell surface associated
HGNC id 7511
Location 3q13.3      Physical location : 124.624.288 - 124.653.580
Synonym name
  • downregulated in colon cancer 1
  • mucin 13, epithelial transmembrane
  • Synonym symbol(s) DRCC1, FLJ20063, MUC-13, RECC
    DNA
    TYPE functioning gene
    STRUCTURE 29.30 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2961 54.6 511 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine  highly
     intestinesmall intestine  moderately
     stomach   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
     respiratory tracttrachea  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivegoblet
    Respiratorygoblet cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal mucin repeat domain
  • three epidermal growth factor-like sequences
  • a SEA module
  • a transmembrane domain
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to mucine Ly64
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in barrier function in epithelial tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • beta subunit produced by cleavage of MUC13 and containing the cytoplasmic tail undergoes homodimerization
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS