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FLASH GENE
Symbol LTK contributors: mct - updated : 22-10-2019
HGNC name leukocyte tyrosine kinase
HGNC id 6721
Location 15q15.1      Physical location : 41.795.839 - 41.806.085
Synonym name protein tyrosine kinase 1
Synonym symbol(s) TYK1
EC.number 2.7.1.112/2.7.10.1
DNA
TYPE functioning gene
STRUCTURE 10.25 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3072 - 864 - 2012 22347506
18 - 2889 - 803 - 2012 22347506
18 - 2682 - 734 - 2012 22347506
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 mouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY ROS/insulin receptor family of tyrosine kinases
CATEGORY signaling , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
text
  • ER-resident receptor tyrosine kinase
  • basic FUNCTION
  • probably a receptor with a tyrosine-protein kinase activity
  • fate specification of iridophores is the first identified role for LTK
  • probably physiological role of LTK in the regulation of iridophore proliferation by homotypic competition
  • physiological link between augmentor ligands (ALKAL1, ALKAL2) and LTK and particular augmentors activate LTK in a tissue-specific context to induce iridophore differentiation from neural crest-derived cells and pigment progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • LTK-to-PREB signaling represents the first example of an ER-resident signaling module with the potential to regulate proteostasis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ALKAL1 stimulates LTK phosphorylation in a ligand-dependent manner
  • ALKAL1 is specific for LTK and only weakly binds to ALK
  • ALKAL2 binds and robustly activates both ALK and LTK
  • LTK in neural crest cells interacts with MDK emanating from the non-neural ectoderm to promote cell survival, revealing a new signaling pathway that is essential for neural crest development
  • LTK interacts with and phosphorylates PREB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    aberrant activation of LTK may contribute to neoplastic cell growth
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism SNP increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS