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FLASH GENE

Symbol

RHOQ

contributors: npt/ - updated : 25-05-2013

HGNC name	ras homolog gene family, member Q
HGNC id	17736

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p21      Physical location : 46.769.866 - 46.811.825
Synonym name	ras-like protein,small GTP binding protein
	ras-like protein TC10
	RAS-like, family 7, member A
Synonym symbol(s)	ARHQ,TC10, TC10A , RASL7A

DNA

TYPE	functioning gene
STRUCTURE	41.96 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012249 5 - 4542 22.53 205 - 2002 11821390

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a RAS domain

conjugated

LipoP

HOMOLOGY

interspecies

homolog to murine Tc10l

intraspecies	homolog to RAC3
	homolog to CDC42
	homolog to RAC1

Homologene

FAMILY	small GTPase superfamily
	Rho family

CATEGORY

signaling , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	cholesterol enriched microdomains (lipid rafts)

basic FUNCTION	involved in the control of microfilament assembly
	playing a role in insulin stimulated glucose uptake and GLUT4 (SLC2A4) translocation
	specifically required for insulin-stimulated glucose uptake in adipocytes
	RHOQ and EXOC7 are essential for the polarized externalization of IGF1 receptor, and this process is necessary for axon specification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	intracellular lipid and protein transport

PATHWAY

metabolism

signaling

signaling pathway in skeletal muscle that involves obscurin and the Rho GTPase RHOQ and implicate this pathway in new sarcomere formation

a component

INTERACTION

DNA

RNA

small molecule

protein	regulating both total and plasma membrane CFTR expression by interacting with CFTR-associated ligand (CAL/GOPC)
	ARHGAP33 may act as a downstream effector of RHOQ in the regulation of insulin-stimulated glucose transport
	OBSCN is a specific activator of RHOQ but not the Rho GTPases RAC1 and CDC42
	small Rho-like GTPase RHOQ stimulates ARHGEF9-dependent GPHN clustering by binding in its active, GTP-bound state to the pleckstrin homology domain of ARHGEF9

cell & other

REGULATION

activated by

GRF2 (C3G-CRK complex) in lipid rafts

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

elevated Rhoq activity contributes to v-Rel-transformed chicken embryonic fibroblasts and demonstrate for the first time that a Rho factor alone is capable of inducing the transformation of primary cells (Tong 2007)