basic FUNCTION
| playing a role in glucose regulation and suppressing insulin ability to stimulate glucose uptake into adipose cells |
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may be playing a role in mediating hyperglycemia associated with obesity |
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playing a role for the central regulation of adipogenesis and adipocyte metabolism |
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activates human endothelial cells (inducing the up-regulation of cell adhesion molecules), interferes in cytokines signaling and could contribute by specific mechanisms to the tailoring of the micro-inflammatory milieu |
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hormone that potentially links obesity to diabetes |
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can dramatically reduce apoptosis and infarct size, thus protecting the heart against infarct size/risk injury |
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structural conformation of resistin may be involved in maintaining the very fine balance in regulation of macrophage function for successful response to a variety of pathological conditions |
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may play a role in the innate immune response against intra-amniotic infection |
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up-regulated CX3CL1 in endothelial cells at comparable level to that of TNF by a mechanism involving MAPK14 and JNK MAPK and NF-kappaB) |
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adipokine correlated with inflammatory markers and is predictive for cardiovascular diseases |
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should not be considered only as an adipokine and LPS-induced inflammation does not affect resistin protein synthesis in liver and adipose tissue |
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key mediator of arthritis accumulating in the inflamed joints and exerting its pro-inflammatory properties independently of TNFalpha |
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having a potential role in atherosclerosis and especially its involvement in acute coronary syndrome |
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may play a role in the regulation of pancreatic beta-cell function |
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LEP, RETN, TNF may have differentiating roles in the pathogenesis of Systemic sclerosis (SSc) |
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RETN, S100A12 and AGER are involved in the pathophysiology of Kawasaki disease (KD) |
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inhibits myogenic differentiation and induces insulin resistance in myocytes |
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is a novel hormone that is secreted by human adipocytes and mononuclear cells and is associated with obesity, insulin resistance and inflammation |
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promotes the expression of vascular endothelial growth factor in ovary carcinoma cells |
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plays an important role in inducing hepatic insulin resistance |
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may affect lipid metabolism during adipocyte maturation |
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may play a role in the process of inflammation and also in the pathophysiology of type 1 diabetes mellitus (T1DM) |
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inflammatory protein, that additionally exhibited chaperone-like properties, suggesting a possible link between inflammation and cellular stress |
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RETN and EDN1 have been reported to inhibit adipogenesis and regulate adipocyte insulin resistance, respectively |
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is a cytokine that induces low-grade inflammation by stimulating monocytes |
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is a pro-inflammatory cytokine involved in the pathogenesis of autoimmune diseases |
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RETN, and LEP may have some impacts on the fetal growth and development |