Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FOLR3 contributors: mct - updated : 27-12-2017
HGNC name folate receptor 3 (gamma)
HGNC id 3795
Location 11q13.4      Physical location : 71.846.770 - 71.850.934
Synonym symbol(s) FRG, FR-G, FR-gamma, gamma-hFR
EC.number 3.1.3.11
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 4.18 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure Sp1 and ets binding elements exist in proximal promoter for transcriptional activity
MAPPING cloned Y linked   status provisional
regionally located telomeric of the FGF3 locus
RNA
TRANSCRIPTS type messenger
text two isoforms produced by alternative splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 882 - 245 - 1994 8110752
5 splicing 1010 - 154 - 1994 8110752
gamma short form
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Lymphoid    
cell lineage hematopoietic
cell lines ovarian and uterine carcinomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twenty three AA signal peptide,sixteen conserved cysteine residues,three potential N linked glycosylation sites
secondary structure eight disulfide bonds
conjugated GlycoP
HOMOLOGY
interspecies homolog to C.elegans F17B5.5
intraspecies homolog to FOLR1,FOLR2
Homologene
FAMILY folate receptor family
CATEGORY transport
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,cytosolic,granule
text secreted and GPI membrane anchored
basic FUNCTION
  • delivery of 5 methyltetrahydrofalate to the interior of cells
  • FOLR1, FOLR2, and FOLR3 are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text folate transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein folate acid and several reduced folic acid derivatives
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    loss of function variants in genes involved in folate transport in MM subjects
    tumoral     --over  
    higher FOLR1 and FOLR3 mRNA levels in ovarian carcinomas compared with both breast carcinomas and mesotheliomas
    constitutional     --over  
    ADRB2, FOLR3 and GSTM1 were upregulated in the monocytes of patients with early onset coronary artery disease
    Susceptibility to Meningomyelocele (MM)
    Variant & Polymorphism SNP rs7925545, rs7926875, rs 7926987 statistically significant for association to MM
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS