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FLASH GENE
Symbol STK17A contributors: npt/ - updated : 17-05-2006
HGNC name serine/threonine kinase 17a
HGNC id 11395
Location 7p14-p12      Physical location : 43.622.691 - 43.666.977
Synonym name
  • death-associated protein kinase-related 1
  • serine/threonine kinase 17a (apoptosis-inducing)
  • Synonym symbol(s) DRAK1, SI7A
    EC.number 2.7.1.37, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 44.29 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3949 46.5 414 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   lowly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivemale systemprostate  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal kinase domain
  • a regulatory domain of kinase activity in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • DAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylates the myosin light chain (mlc)
  • autophosphorylation
  • involved in osteoclast apoptosis
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text induction of apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS