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FLASH GENE
Symbol CTTNBP2 contributors: mct - updated : 13-02-2019
HGNC name cortactin binding protein 2
HGNC id 15679
Location 7q31.31      Physical location : 117.350.707 - 117.513.561
Synonym symbol(s) KIAA1758, CORTBP2, C7orf8, Orf4, FLJ34229, MGC104579
DNA
TYPE functioning gene
STRUCTURE 163.17 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - ST7 - WNT2 - CFTR - D7S677 - CTTNBP2 - D7S1427 - D7S1902 - KCND2 - D7S1436 qter
Authors Cheung (01)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 5980 - 1663 - 1998 9813110
23 - 6108 - 1645 - 1998 9813110
23 - 5751 - 964 - 1998 9813110
23 - 5741 - 964 - 1998 9813110
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six,33 AA ankyrin repeats
  • proline-rich region
  • HOMOLOGY
    intraspecies homolog to CTTNBP2NL
    Homologene
    FAMILY ezrin/radixin/moesin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • in addition to F-actin, CTTNBP2 also associates with microtubules before mature dendritic spines form
  • basic FUNCTION
  • may thus help to immobilize cortactin in dendritic spines and control the density of dendritic spines
  • CTTNBP2, a neuron-specific protein, regulates the mobility and distribution of cortactin and controls the density of dendritic spines
  • neuron-specific F-actin regulator, shown to play a role in the regulation of dendritic spine formation and their maintenance
  • CTTNBP2 influences both the F-actin and microtubule cytoskeletons and regulates dendritic spine formation and dendritic arborization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CTTNBP2 proteins form a dimer or oligomer and brings multiple microtubule filaments together to form bundles
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complex striatin-interacting phosphatase and kinase (STRIPAK), can establish mutually exclusive interactions with the cortactin-binding proteins cortactin-binding protein 2 (CTTNBP2)/cortactin-binding protein 2, N-terminal-like (CTTNBP2NL) or with an assembly of sarcolemmal membrane-associated protein (SLMAP)
  • CTTNBP2 modulates the mobility of cortactin in neurons
  • interacts with cortactin to regulate cortactin mobility and control dendritic spine formation
  • in addition to spine morphology, CTTNBP2 is also found to regulate the synaptic distribution of striatin and zinedin
  • CTTNBP2 targets the PP2A complex to dendritic spines
  • interactions of CTTNBP2 and cortactin and the PP2A complex regulate spine morphogenesis and synaptic signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS