| basic FUNCTION
| acting as a NAD-dependent deacetylase |
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activating mitochondria functions and playing an important role in adaptive thermogenesis in brown adipose |
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may play a role in life span |
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important for regulation of mitochondrial metabolism, cell survival, and longevity  |
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major mitochondrial deacetylase, having evolved to control reversible lysine acetylation in the mitochondria |
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can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase |
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essential role of SIRT3 in the survival of cardiomyocytes in stress situations |
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might function in nucleus |
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by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers |
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NAD(+)-dependent protein deacetylases that regulate cellular functions through deacetylation of a wide range of protein targets |
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required to maintain cell survival after genotoxic stress in a NAD+-dependent manner |
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with SIRT4, modulate mitochondrial function in response to its [NADH]/[NAD+] ratio by regulating the activity of key metabolic enzymes |
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stimulates deacetylation of MRPL10, consequently regulating protein synthesis in mammalian mitochondria |
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mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress |
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essential player in enhancing the mitochondrial glutathione antioxidant defense system during caloric restriction suggesting that SIRT3-dependent mitochondrial adaptations may be a central mechanism of aging retardation, and age-related hearing loss |
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during caloric restriction, promotes a more reductive environment in mitochondria of multiple tissues, thereby enhancing the glutathione antioxidant defense system |
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mediates reduction of oxidative stress by stimulating IDH2 activity and increasing NADPH levels under stress conditions |
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integral regulator of mitochondrial function and its depletion results in hyperacetylation of critical mitochondrial proteins that protect against hepatic lipotoxicity under conditions of nutrient excess |
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acts as a tumor suppressor via its ability to suppress reactive oxygen species (ROS) and regulate hypoxia inducible factor 1A (HIF1A) |
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acts to suppress the growth of tumors, at least in part through its ability to suppress ROS and HIF1A |
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SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity |
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plays an important role in diabetes through regulation of mitochondrial oxidation, reactive oxygen species production, and insulin resistance in skeletal muscle |
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link between SIRT3, mitochondrial DNA variability and mitochondrial functionality, three fundamental components of the cellular stress response |
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SIRT3-mediated deacetylation has recently emerged as a major mechanism regulating the activity of mitochondrial oxidative and intermediary metabolism |
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key role for SIRT3 in the maintenance of oxidative metabolism that may be especially important in the heart |
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SIRT3 is a potential regulator of IDH2-dependent functions in cancer cell metabolism |
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can protect cells from mitochondrial oxidative stress and this effect is almost entirely dependent on IDH2 |
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key factor in a coordinate up-regulation of oxidative metabolism and antioxidant pathways in response to acute and chronic caloric restriction |
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exhibits a previously unappreciated role in the nucleus, modulating the expression of some stress-related and nuclear-encoded mitochondrial genes |
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plays an important role in skeletal muscle mitochondrial substrate choice and metabolic flexibility in part by regulating PDH function through deacetylation |
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role for SIRT3 in the suppression of epidermal differentiation via lowering oxidative stress |
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novel function of SIRT3 which was found to be involved in mitosis |
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is not a tubulin deacetylase but regulates the attachment of spindle microtubules to the kinetochore and the subsequent chromosome alignment by increasing spindle dynamics |
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major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions |
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acts as a prosurvival factor playing an essential role to protect cortical neurons under H2O2 induced oxidative stress, possibly through regulating mitochondrial Ca2+ homeostasis and mitochondrial biogenesis |
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role in keratinocyte differentiation, wound healing, chronological aging, ultraviolet radiation (UVR) and ozone response, systemic sclerosis, melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) |
