basic FUNCTION
| inhibits cytokine signaling |
|
neither endogenous nor exogenously expressed ASB2 induces degradation of JAK proteins in hematopoietic cells |
|
is a critical regulator of cell spreading and podosome rosette formation in immature dendritic cells (DCs) |
|
regulates hematopoietic cell differentiation by modulating cell adhesion, spreading, and actin remodeling through targeted degradation of filamins |
|
FLNA is known to play roles in cytoskeleton organization and to be required for heart function, and its degradation mediated by ASB2 ensures essential functions in differentiating cardiac progenitors |
|
ASB2 requirement for embryonic survival and complete heart looping, and for human cardiomyocyte differentiation |
|
|