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FLASH GENE
Symbol GNG11 contributors: npt/mct - updated : 15/102008
HGNC name guanine nucleotide binding protein (G protein), gamma 11
HGNC id 4403
Location 7q21.3      Physical location : 93.551.015 - 93.555.824
Synonym name
  • G protein gamma-11 subunit
  • guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit
  • Synonym symbol(s) GNGT11, IG, SG
    DNA
    TYPE functioning gene
    STRUCTURE 4.81 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 964 8.5 73 ubiquitous but not in brain Hossain (2006)
    - - - 1200 - - ubiquitous but not in brain -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure alpha, beta, gamma subunit
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans K02A4.2
    Homologene
    FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • plays a role in the transmembrane signaling system
  • mediating a senescence pathway in response to environmental cues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterotrimeric G protein complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by senescence-inducing agents such as H(2)O(2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in splenic marginal zone lymphomas
    constitutional     --over  
    immediately induces cellular senescence in normal fibroblasts, and its down-regulation by antisense cDNA extends their lifespan
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS