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FLASH GENE
Symbol CTNNBIP1 contributors: mct - updated : 27-10-2012
HGNC name catenin, beta interacting protein 1
HGNC id 16913
Location 1p36.22      Physical location : 9.908.333 - 9.970.316
Synonym name inhibitor of beta-catenin and T-cell factor
Synonym symbol(s) ICAT, MGC15093
DNA
TYPE functioning gene
STRUCTURE 61.98 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2961 - 81 - 2002 12408824
6 - 2995 - 81 - 2002 12408824
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunetonsils   highly
Nervousbrain   highly
Reproductivemale systemtestis  lowly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
text
  • in pancreas, displayed a cell-type-specific distribution; in acinar and endocrine cells, it was nuclear, whereas in ductal cells, it was cytoplasmic
  • basic FUNCTION
  • negatively regulating Wnt signaling via inhibition of the interaction between beta catenin and TCF4 and required in development and cell proliferation
  • playing an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of WNT signaling
  • negative regulator of the Wnt signaling pathway that interferes with the interaction between beta-catenin and T cell factor
  • participated in regulating adipose tissue-derived stromal cells proliferation and differentiation by modulating WNT signaling
  • potential enhancer of monocytic differentiation
  • functions as a crucial node to mediate the cross talk between E2F1 and CTNNB signaling
  • regulates the Wnt pathway and cell proliferation
  • regulates acinar differentiation and it does so through a novel Wnt pathway-independent mechanism that may contribute to pancreatic disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta catenin
  • activation of CTNNBIP1 by E2F1 is required for E2F1 to inhibit CTNNB activity
  • modulates androgen receptor activity
  • CTNNBIP1 is a novel PTF1A interactor, and regulates negatively PTF1A activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    causes the arrest of ureteric bud and the the apoptotic death of metanephric mesenchymal cells, resulting in renal agenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS