basic FUNCTION
| Ca2+ sensor in the process of vesicular trafficking and exocytosis |
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overexpression of synaptotagmin-4 shortened the time from fusion pore opening to dilation |
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promote transmitter release independently of Ca(2+) binding in the C(2)A domain |
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Syt IV-mediated gliotransmission contributes to hippocampal-based memory |
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serves as a postsynaptic Ca2+ sensor to release retrograde signals and induces presynaptic release and synapse-specific growth |
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an important regulator of release from nerve terminals |
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can either enhance or inhibit Ca2+ - triggered exocytosis, depending on the amount of Ca2+ entry |
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negatively regulates OXT exocytosis, and dietary obesity is associated with increased vesicle binding of synaptotagmin-4 and thus enhanced negative regulation of OXT release |