protein
| plays a pivotal role in cellular differentiation through a mechanism related to the regulation of transactivation of RUNX2 essential for osteoblastogenesis toward maturation in osteoblastic cells |
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TP53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of cell death, by repressing expression of SLC7A11, a key component of the cystine/glutamate antiporter |
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TP53 can enhance ferroptosis by inhibiting the expression of SLC7A11 or by enhancing that of SAT1 and GLS2 |
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cystine transporter SLC7A11 is a key BAP1 target gene in human cancers |
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OTUB1 directly interacted with and stabilized SLC7A11 |
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OTUB1 plays an essential role in controlling the stability of SLC7A11 and the CD44-mediated effects on ferroptosis in human cancers |
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BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression |
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BAP1 regulates ferroptosis through SLC7A11 |
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DAZAP1 interacted with the 3'UTR (untranslated region) of SLC7A11 mRNA and positively regulated its stability |
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TRIM26 physically interacted with solute carrier family-7 member-11 (SLC7A11), a critical protein for lipid reactive oxygen species (ROS) scavenging, and mediated its ubiquitination |
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SOX2-SLC7A11 regulatory axis that confers resistance to ferroptosis in lung cancer stem-like cells |