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FLASH GENE
Symbol SLC7A11 contributors: mct - updated : 08-03-2022
HGNC name solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
HGNC id 11059
Location 4q28.3      Physical location : 139.085.247 - 139.163.503
Synonym name
  • cystine/glutamate transporter
  • calcium channel blocker resistance protein CCBR1
  • Synonym symbol(s) XCT, CCBR1
    DNA
    TYPE functioning gene
    STRUCTURE 78.25 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 9645 - 501 - 2021 34609966
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     mouthtongue   
     stomach   highly
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    twelve transmembrane domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Xct
    Homologene
    FAMILY
  • solute carrier family 7
  • amino acid permeases family
  • glycoprotein associated amino acid transporter (gpaat) subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in sodium-independent, high-affinity exchange of anionic amino acids with high specificity
  • for anionic form of cystine and glutamate
  • major genetic regulator of pheomelanin pigment in hair and melanocytes, with minimal or no effects on eumelanin, and controling the production of pheomelanin pigment
  • directly
  • has a critical role in the generation of glutathione and the protection of cells from oxidative stress
  • promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death
  • also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells
  • ferroptosis is triggered by lipid peroxidation and is tightly regulated by SLC7A11, a key component of the cystine-glutamate antiporter
  • imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text cysteine/glutamate antiporter
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide linked with SLC3A2/4F2HC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays a pivotal role in cellular differentiation through a mechanism related to the regulation of transactivation of RUNX2 essential for osteoblastogenesis toward maturation in osteoblastic cells
  • TP53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of cell death, by repressing expression of SLC7A11, a key component of the cystine/glutamate antiporter
  • TP53 can enhance ferroptosis by inhibiting the expression of SLC7A11 or by enhancing that of SAT1 and GLS2
  • cystine transporter SLC7A11 is a key BAP1 target gene in human cancers
  • OTUB1 directly interacted with and stabilized SLC7A11
  • OTUB1 plays an essential role in controlling the stability of SLC7A11 and the CD44-mediated effects on ferroptosis in human cancers
  • BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression
  • BAP1 regulates ferroptosis through SLC7A11
  • DAZAP1 interacted with the 3'UTR (untranslated region) of SLC7A11 mRNA and positively regulated its stability
  • TRIM26 physically interacted with solute carrier family-7 member-11 (SLC7A11), a critical protein for lipid reactive oxygen species (ROS) scavenging, and mediated its ubiquitination
  • SOX2-SLC7A11 regulatory axis that confers resistance to ferroptosis in lung cancer stem-like cells
  • cell & other
    REGULATION
    inhibited by glucose starvation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    promotes cancer cell survival upon glucose starvation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SLC7A11 may be a vital biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma (LSCC)
  • overexpression might be a novel biomarker and a potential unfavorable prognostic factor
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    targeting SLC7A11 appears to be a potentially significant method for LSCC treatment
    cancerdigestiveliver
    potential therapeutic target for liver carcinoma
    ANIMAL & CELL MODELS