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FLASH GENE

Symbol

CXCL13

contributors: mct/npt/pgu - updated : 25-06-2010

HGNC name	chemokine (C-X-C motif) ligand 13
HGNC id	10639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q21.1      Physical location : 78.432.906 - 78.532.986
Synonym name	chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
	B-cell-homing chemokine (ligand for Burkitt's
	small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)lymphoma receptor-1)
	B-cell chemoattractant
	CXC chemokine BLC
Synonym symbol(s)	BLC, BCA1, ANGIE, BCA-1, SCYB13, BLR1L, ANGIE2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	100.08 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006419 5 - 1219 NP_006410 - 109 - 1998 9486651

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           intestine large intestine caecum appendix vermicular     liver       highly   salivary gland           stomach         Lymphoid/Immune lymph node       highly   spleen       highly Reproductive female system breast mammary gland   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	lowly in spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Blc

Homologene

FAMILY	intercrine alpha (chemokine CxC) family
	chemokine CXC subfamily

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
text	soluble fraction

basic FUNCTION	required for B1 cell homing, natural antibody production and body cavity immunity
	chemotactive for B lymphocytes and activated T cell
	playing an important role not only in the formation of normal gut associated lymphoid tissue but also in the generation of aberrant lymphoid tissue in inflammatory bowel disease
	homeostatic chemokine for lymphocyte homing and positioning within follicles of secondary lymphoid tissues, acting through its cognate receptor, CXCR5

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

inflammation

text	anti-pathogen response
	cytosolic calcium ion concentration elevation
	chemotactive for B lymphocytes

PATHWAY

metabolism

signaling

signal transduction

	cell to cell signaling
	. CXCL13/CXCR5 signaling effect on shaping B-cell dynamics is an effective mechanism that enhances antigen encounter and BCR-triggered B-cell activation

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand of CXCR5 (CXCL13-CXCR5 axis is significantly associated with prostate cancer progression)

cell & other

REGULATION

inhibited by	by antibody against CXCR3 (BCA1 induced chemotaxis)
	transiently down-regulated within lymphoid tissues during immune responses by a mechanism controlled by the cytokine interferon-gamma

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   with its receptor, CXCR5 in B-cell chronic lymphocytic leukemia tumoral     --over   in breast cancer, significantly elevated serum concentrations of CXCL13 in patients with metastatic disease

Susceptibility

to ulcerative colitis

Variant & Polymorphism

Candidate gene
Marker	prognostic marker for oral squamous cell carcinoma development and progression
	marker that appears to be helpful in clinically atypical cases of Lyme neuroborreliosis, and, in particular, in early stages of the disease when the B burgdorferi AI is (still) negative
Therapy target
	System Type Disorder Pubmed cancer reproductive breast might serve as a useful therapeutic target and/or diagnostic marker in this malignancy cancer head and neck   potential therapeutic target to prevent oral squamous cell carcinoma bone invasion/osteolysis

ANIMAL & CELL MODELS

blc knock out mice