motifs/domains
| three N terminal ankyrin (ANK) repeats |
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six transmembrane spanning domains with a pore forming region between transmembrane domains 5 and 6 |
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ankyrin repeat |
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six transmembrane domain containing receptor |
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putative coiled-coil domain |
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putative sites for protein kinase A phosphorylation and for N-glycosylation |
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CRAC motifs, cholesterol-binding motifs  |
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a C terminal Walker A motif and cytoplasmic tail with a phosphatidylinositol-4,5-bisphosphate binding domain, and a calmodulin binding motif forming an alpha helix that docks into the central cavity of calmodulin (distal C-terminal region was proposed to bind to INPP5J, inhibiting the channels, but it is not required for this binding) |
| basic FUNCTION
| non selective cation channel, integrating multiple noxious stimuli |
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acts as a molecular detector of noxious stimuli in the peripheral nervous system |
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molecular sensor of noxious heat and capsaicin |
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ion channel that is enriched in sensory neurons and involved in pain perception |
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increasing in intracellular calcium |
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may be involved in the control of emotions, learning, satiety and in integration of painful stimuli |
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mediating inflammatory rather than acute thermal pain |
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acting as proton channel to induce acidification in nociceptive neurons |
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may play a role in non-neuronal mechanisms that might modulate nociception in symptomatic osteoarthritis and rheumatoid arthritis patients |
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has a role in visceral pain and inflammation aggravated by alcohol |
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is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia |
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a role in normal bladder function, particularly in the detection of mechanical stimuli by the urothelium |
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contributes to pressure sensing and ca2+ dependent cell death |
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involved in nuclear translocation of NFkB and the inflammatory cytokine IL-6 with exposure to hydrostatic pressure in vitro |
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may play a role in maintaining normal levels of Ca2+ in retinal ganglion cells |
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plays a key role in the perception of peripheral thermal and inflammatory pain |
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seems to play a significant role in the development of peripheral and central sensitisation and of hyperalgesia and allodynia, and in migraine |
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the outer pore channel of TRPV1 is important for the heat sensitivity of transient receptor potential ion channels |
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essential component of inflammatory hyperalgesia |
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TRPV1 and TRPA1, are necessary for development of inflammatory hypersensitivity and are functionally potentiated by growth factors |
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TRPV1 and TRPA1 induced MUC5B release in the nasal airways |
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TRPV1 agonists induce long-term receptor down-regulation by modulating the expression level of the channel through a mechanism that promotes receptor endocytosis and degradation |
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capsaicin-induced TRPV1 endocytosis and degradation in nociceptors notably contribute to the long-term neuronal tachyphylaxis induced by vanilloids |
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TRPV1 channel has been found to be an important player in the pathway of the detection of chest pain after myocardial injury |
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role of TRPM2 and TRPV1 cation channels in cellular responses to radiation-induced DNA damage |
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TRPV1 and TRPA1 in vestibular ganglion (VG) neurons might participate in vestibular function and/or dysfunction such as vertigo |
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TRPA1, like TRPV1, mediates F2RL1-triggered pancreatic nociception and that TRPA1 in collaboration with TRPV1 latently contributes to pancreatitis-related pain |
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plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions |
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central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain |
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TRPV1, TRPA1, and TRPM8 are important to start up a systemic response of energy expenditure, energy allocation, and water retention |
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activation of ASIC3 and TRPV1 as well as enhanced SCN10A activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain |
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regulates the activation and proinflammatory properties of CD4& |
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8314; T cells |
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cross-talk between ADARA1D and TRPV1, that is involved in the control of prostate carcinoma cell proliferation |
