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FLASH GENE
Symbol CYP2S1 contributors: - updated : 08-06-2007
HGNC name cytochrome P450, family 2, subfamily S, polypeptide 1
HGNC id 15654
Location 19q13.1      Physical location : 41.699.114 - 41.713.443
EC.number 1.14.14.1
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine   
 intestinelarge intestinecolon moderately
 mouth   predominantly
 stomach   moderately
Lymphoid/Immunespleen    
Respiratorylung    
 respiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Cyp2s1 (74.3 pc)
homolog to murine Cyp2s1 (79 pc)
intraspecies homolog to CYP2
Homologene
FAMILY
  • cytochrome P450 subfamily IIS
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • acting as a monooxygenase
  • involved in the hydroxylation of xenobiotics
  • having a potential importance for extrahepatic xenobiotic metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
  • oxydative metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS