protein
| interacts with CROCC |
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interaction between CEP135 and CEP250, two core centriolar proteins |
|
AXIN2, a negative regulator of beta-catenin, localizes at the centrosomes by binding to the centriole-associated component CEP250 |
|
SIK2 plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, CEP250, through S2392 phosphorylation |
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interaction with PLK1 (PLK1 is required for both CEP250 displacement and for KIF11 localization on the centrosome) |
|
interaction partners of CEP135, the 50 kDa subunit of the dynactin complex (DCTN2) and CEP250, have their binding sites in the C-terminal domain of CEP135 |
|
recruitment of NEK2 to the proximal ends of centrioles is dependent on one of its substrates, the centrosome cohesion protein CEP250 |
|
LRRC45 interacts with both CEP250 and CROCC and is phosphorylated by NEK2 at S661 during mitosis |
|
CNTLN localizes to the proximal ends of the centrioles and directly interacts with both CEP250 and CEP68 |
|
phosphorylation of CEP250 perturbs interaction with the core centriolar protein, CEP135, and interaction of endogenous CEP250 and CEP135 proteins is specifically lost in mitosis |
|
centriolar loading of SCYL1 stimulated by EGF/AKT could displace CEP250, resulting in centrosome splitting |
|
centriolar protein CNTLN functions as a molecular link between CEP250 and CEP68 to maintain centrosome cohesion |