basic FUNCTION
| may be involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation |
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plays an important role in the assembly and maintenance of eukaryotic cilia |
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negatively regulates the SHH pathway in the cilium at a step downstream of the SHH ligand and the transmembrane protein Smoothened, but upstream of the GLI2 transcription factor |
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controls the ciliary localization of Shh pathway regulators in different ways |
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like DYNC2H1, is required for retrograde ciliary trafficking, but reduction of IFT122 gene dosage also suppresses the DYNC2H1 phenotype |
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may not directly carry any precursors for flagellar assembly, but it controls how many IFT particles participate in ferrying precursors into flagella |
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IFT122 is required for the efficient transport of opsin and the distal elongation of outer segments |
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encodes a protein responsible for the retrograde transport along the cilium |
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binding of IFT22 to the intraflagellar transport complex is likely essential for flagellum assembly |
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IFT22 is an active GTPase with low intrinsic GTPase activity |
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nucleotide-dependent recruitment of the BBSome to the basal body by IFT22 regulates BBSome entry into cilia |