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FLASH GENE
Symbol BCL3 contributors: mct - updated : 07-07-2010
HGNC name B-cell CLL/lymphoma 3
HGNC id 998
Location 19q13.32      Physical location : 45.251.977 - 45.263.300
Synonym name
  • B-cell lymphoma 3-encoded protein
  • protein Bcl-3
  • chronic lymphatic leukemia protein
  • proto-oncogene BCL3
  • Synonym symbol(s) BCL4, D19S37, BCL-3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.32 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1864 - 454 - 2010 20226764
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   predominantly
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain is an essential region for the degradation, transcriptional activity, and oncogenic potential of TBL1XR1
  • seven ANK repeats, an ankyrin repeat domain, which is known to bind several nuclear proteins (for interaction with IRS3L)
  • HOMOLOGY
    interspecies ortholog to murine Bcl3
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibitor of REL/NFKB transcription factors
  • regulator of development differentiation apoptosis
  • functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with CRTC3
  • involved in the regulation of CRE-mediated transcription through its association with CRTC3
  • synergize with PPARGC1A to coactivate ESRRA
  • cytokine-stimulated transcriptional regulator, that is an ESRRA coactivator
  • potential oncogenic role for BCL3 in mutiple myeloma
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • ESRRA, PPARGC1A, and BCL3 form a complex on an ESRRA-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac myocytes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • N4BP2
  • COPS5
  • interacting with CRTC3 through the ankyrin repeat domain of BCL3
  • cooperativity between BCL3 and PPARGC1A may serve as a point of convergence on nuclear receptor targets to direct programs orchestrating inflammatory and energy metabolism responses in heart and other tissues
  • interact tightly with the NF-KB p50 homodimer (Kabuta 2010)
  • interacting with CTBP1 (required for the ability of BCL3 to repress gene transcription, CTBP1 is also required for the oncogenic potential of BCL3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes)
  • cell & other
    REGULATION
    activated by by phosphorylation
    CNTN2 (upregulation that may help to mediate these effects of CNTN2 to promote cell proliferation)
    induced by IL6 via STAT3 binding to intronic enhancer HS4 and represses its own transcription
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in chronic lymphocytic leukemia and non Hodgkin lymphoma in t(14;19)(q32-q13)
    constitutional     --over  
    increases apoptosis
    tumoral     --over  
    in human myeloma cells is associated with increased proliferation and inferior prognosis
    Susceptibility to Crohn disease
    Variant & Polymorphism SNP
  • rs2927488 in BCL3 significantly associated with Crohn disease (Pubmed 20601676)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS