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Symbol F11R contributors: mct - updated : 16-12-2014
HGNC name F11 receptor
HGNC id 14685
Location 1q23.3      Physical location : 160.965.001 - 160.991.133
Synonym name
  • platelet adhesion molecule PAM-1
  • platelet F11 receptor
  • junctional adhesion molecule 1
  • junctional adhesion molecule A
  • CD321 antigen
  • Synonym symbol(s) JAM, JAM1, PAM-1, JAM-1, KAT, JCAM, CD321, JAMA, CD321
    TYPE functioning gene
    STRUCTURE 26.13 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure
  • P1 is a TATA-less promoter containing an initiator element, multiple transcription start sites, several GC and CCAAT boxes, and GATA, NF-kappaB and ets consensus sequences
  • promoter P2, located upstream of P1, contains a TATA box, GC boxes, a CCAAT box and GATA and ets consensus sequences
  • MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    text multiple transcripts, with two alternative promoters, P1 and P2
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4830 - 299 - 2006 16418218
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiensAdult
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
     pharynx   highly
    Lymphoid/Immunelymphatic vessel     Homo sapiensAdult
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Cardiovascularendothelial cell Homo sapiensAdult
    cell lineage hematopoietic cells of cell lineages
    cell lines breast, colon, lung carcinoma cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
  • a N terminal signal peptide
  • two potential N glycosylation sites
  • an extracellular domain containing two extracellular IgV or C2-type loops
  • a short C terminal tail with a PDZ domain
    interspecies homolog to murine Jcam1
  • JAM family
  • CATEGORY adhesion , immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    intracellular,nuclear envelope
    text integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles
    basic FUNCTION
  • regulating the tight junction assembly in epithelia
  • counter-receptor for LFA1 controling transmigration during leukocyte recruitment
  • cell adhesion molecule of the immunoglobulin superfamily involved in platelet adhesion, secretion
  • plays a critical role in the function of endothelial cells and in platelet adhesion to inflamed endothelium
  • having with NKkappa B a function in the initiation of inflammatory thrombosis
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • in addition to the previously reported role of F11R in the initiation of plaque formation, F11R plays also an important role in the subsequent growth of atherosclerotic plaques
  • restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting AKT1-dependent CTNNB1 activation
  • unique tight junction (TJ) transmembrane protein that under basal conditions maintains endothelial cell-cell interactions but under inflammatory conditions acts as a leukocyte adhesion molecule
  • potential role in controlling perijunctional actin cytoskeleton in addition to its previously reported role in regulating claudin proteins and small-molecule permeability
  • cell adhesion molecule found on the surface of human platelets
  • key regulator of mesoangioblasts (MABs) extravasation
  • serve a crucial role in the proliferation, differentiation, and tube-like formation of epithelial cells during angiogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    text platelet aggregation
    a component
    small molecule
  • physically and functionally associated with the PDZ domain-containing MLLT4 and PDZGEF2, but not zonula occludens (ZO)-1, in epithelial cells
  • Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions
  • involvement of RHOA and ROCK1 in F11R relocalization
  • associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
  • regulates epithelial permeability via association with TJP2, afadin, and RAPGEF2 to activate RAP2C and control contraction of the apical cytoskeleton
  • ADAR, but not ADAR2, takes part in the editing of F11R however editing alone is not sufficient for obtaining an elevation in RNA levels
  • plays an important role in non-small cell lung cancer (NSCLC) progression
  • recruits CSK to the integrin-SRC complex in resting platelets
  • cell & other
  • receptor for retrovirus, required for activation NF-kappa B and apoptosis
    Other induced during differentiation of THP-1 dendritic cells and is independent of PPAR-gamma and the p38 MAPK pathway (Ogasawara 2009)